The Fadiman Protocol is one of the most widely practiced microdosing schedules, designed to help people experience the subtle benefits of psychedelics while avoiding tolerance and maintaining balance. Created by psychologist and researcher James Fadiman, the protocol follows a simple rhythm: take a small “sub-perceptual” dose of a psychedelic substance on Day 1, observe the aftereffects on Day 2, and rest on Day 3 before repeating the cycle. This three-day pattern allows the body and mind to integrate insights, track changes in mood and creativity, and minimize the risk of building tolerance.
How the Three-Day Cycle Works
The protocol’s Day 1 – Dose Day begins with a carefully measured microdose, typically about one-tenth to one-twentieth of a standard psychedelic dose. The goal is to feel subtle shifts in mood, focus, or creativity without any hallucinogenic effects.
Day 2 – Observation Day is when many users notice the “afterglow.” People often report enhanced clarity, emotional openness, or improved problem-solving skills that carry over from the dose day.
Day 3 – Reset Day provides a break for the brain’s serotonin receptors, reducing the chance of tolerance and helping the user observe natural baseline mood and energy levels.
Benefits of the Fadiman Protocol
People who follow the Fadiman Protocol often cite benefits such as improved mood, sharper focus, heightened creativity, and reduced anxiety. Because the microdoses are sub-perceptual, the practice fits into everyday life without impairing work or social interactions. The built-in rest days also give participants time to notice subtle shifts and integrate any new perspectives.
Best Practices for Success
- Start Low and Slow: Begin with the smallest possible dose—about 5–10 micrograms of LSD or 0.1–0.3 grams of dried psilocybin mushrooms—and adjust only if needed.
- Keep a Journal: Track dosage, mood, creativity, and any physical effects to spot patterns and ensure safety.
- Commit to a Cycle: A typical course lasts four to eight weeks, after which it’s important to take a break of at least two to four weeks to reset completely.
Safety and Mindfulness
While many people report positive outcomes, microdosing is not risk-free and may not be suitable for everyone. Legal considerations, mental health conditions, and potential drug interactions should all be taken seriously. Approaching the protocol with intention—rather than as a quick fix—creates the best environment for mindful growth.
